Chemical and Biological insights of Ouratea hexasperma (A. St.-Hil.) Baill.: a source of bioactive compounds with multifunctional properties

Nat Prod Res. 2019 May;33(10):1500-1503. doi: 10.1080/14786419.2017.1419227. Epub 2018 Jan 16.

Abstract

The study aimed to evaluate in vitro antioxidant, anticholinesterase and antidiabetic properties of Ouratea hexasperma (A. St.-Hil.) Baill. The inflorescence methanol extract and the ethyl acetate fraction of leaves and stems reported the highest Relative Antioxidant Capacity Index (RACI), whereas the dichloromethane fraction of leaves was the best inhibitor of α-amylase and α-glucosidase. Trans-3-O-methyl-resveratrol-2-C-β-glucoside, lithospermoside, 2,5-dimethoxy-p-benzoquinone, lup-20(30)-ene-3β,28-diol, 7-O-methylgenistein, apigenin and luteolin and amentoflavone were isolated from O. hexasperma. Resveratrol derivative was isolated for the first time in Ochnaceae family. Luteolin, followed by apigenin, reported the highest Relative Antioxidant Capacity Index and they were also the best inhibitors of α-glucosidase enzyme.

Keywords: Biological properties; phytochemical profile.

MeSH terms

  • Antioxidants / chemistry
  • Antioxidants / pharmacology*
  • Apigenin / isolation & purification
  • Apigenin / pharmacology
  • Cholinesterase Inhibitors / chemistry
  • Cholinesterase Inhibitors / pharmacology*
  • Drug Evaluation, Preclinical / methods
  • Glycoside Hydrolase Inhibitors / pharmacology
  • Hypoglycemic Agents / chemistry
  • Hypoglycemic Agents / pharmacology*
  • Luteolin / isolation & purification
  • Luteolin / pharmacology
  • Methanol / chemistry
  • Ochnaceae / chemistry*
  • Plant Extracts / chemistry
  • Plant Leaves / chemistry
  • alpha-Amylases / antagonists & inhibitors

Substances

  • Antioxidants
  • Cholinesterase Inhibitors
  • Glycoside Hydrolase Inhibitors
  • Hypoglycemic Agents
  • Plant Extracts
  • Apigenin
  • alpha-Amylases
  • Luteolin
  • Methanol