Abstract
Fumagillin-loaded liposomes were injected into ApoE-KO mice. The animals were divided into several groups to test the efficacy of this anti-angiogenic drug for early treatment of atherosclerotic lesions. Statistical analysis of the lesions revealed a decrease in the lesion size after 5 weeks of treatment.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Angiogenesis Inhibitors / administration & dosage
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Angiogenesis Inhibitors / therapeutic use*
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Animals
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Apolipoproteins E / genetics
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Atherosclerosis / diagnostic imaging
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Atherosclerosis / drug therapy*
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Atherosclerosis / pathology
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Cyclohexanes / administration & dosage
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Cyclohexanes / therapeutic use*
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Disease Models, Animal*
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Drug Carriers*
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Fatty Acids, Unsaturated / administration & dosage
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Fatty Acids, Unsaturated / therapeutic use*
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Liposomes*
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Magnetic Resonance Imaging
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Mice
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Mice, Knockout
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Nanoparticles*
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Sesquiterpenes / administration & dosage
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Sesquiterpenes / therapeutic use
Substances
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Angiogenesis Inhibitors
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Apolipoproteins E
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Cyclohexanes
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Drug Carriers
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Fatty Acids, Unsaturated
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Liposomes
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Sesquiterpenes
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fumagillin
Grants and funding
Financial support by the Spanish MINECO, ISCIII, FEDER (Projects Consolider-Ingenio CSD2010-000652010 (EGE) and Project CP13/00216 (MTA), and «Unidad de Excelencia María de Maeztu» MDM-2015-0538) and Fundació Gent per Gent (JCF).