Anti-angiogenic drug loaded liposomes: Nanotherapy for early atherosclerotic lesions in mice

PLoS One. 2018 Jan 16;13(1):e0190540. doi: 10.1371/journal.pone.0190540. eCollection 2018.

Abstract

Fumagillin-loaded liposomes were injected into ApoE-KO mice. The animals were divided into several groups to test the efficacy of this anti-angiogenic drug for early treatment of atherosclerotic lesions. Statistical analysis of the lesions revealed a decrease in the lesion size after 5 weeks of treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiogenesis Inhibitors / administration & dosage
  • Angiogenesis Inhibitors / therapeutic use*
  • Animals
  • Apolipoproteins E / genetics
  • Atherosclerosis / diagnostic imaging
  • Atherosclerosis / drug therapy*
  • Atherosclerosis / pathology
  • Cyclohexanes / administration & dosage
  • Cyclohexanes / therapeutic use*
  • Disease Models, Animal*
  • Drug Carriers*
  • Fatty Acids, Unsaturated / administration & dosage
  • Fatty Acids, Unsaturated / therapeutic use*
  • Liposomes*
  • Magnetic Resonance Imaging
  • Mice
  • Mice, Knockout
  • Nanoparticles*
  • Sesquiterpenes / administration & dosage
  • Sesquiterpenes / therapeutic use

Substances

  • Angiogenesis Inhibitors
  • Apolipoproteins E
  • Cyclohexanes
  • Drug Carriers
  • Fatty Acids, Unsaturated
  • Liposomes
  • Sesquiterpenes
  • fumagillin

Grants and funding

Financial support by the Spanish MINECO, ISCIII, FEDER (Projects Consolider-Ingenio CSD2010-000652010 (EGE) and Project CP13/00216 (MTA), and «Unidad de Excelencia María de Maeztu» MDM-2015-0538) and Fundació Gent per Gent (JCF).