Polyclonal B cell activators inhibit contact sensitivity to oxazolone in mice by potentiating the production of anti-hapten antibodies that induce T suppressor lymphocytes acting through the release of soluble factors

Int Arch Allergy Appl Immunol. 1985;78(4):391-5. doi: 10.1159/000233919.

Abstract

Polyclonal B cell activators (PBAs) such as purified protein derivative, lipopolysaccharide, Staphylococcus aureus strain Cowan I (StaCwI), and Pseudomonas aeruginosa inhibit contact sensitivity to oxazolone in mice when given 24 h before sensitization. This suppression, transferable from immunodepressed animals to oxazolone-sensitized recipients with immune serum, has been shown to be due to the early appearance of anti-hapten antibodies. These antibodies elicit T suppressor cells which release soluble factor(s) capable of inhibiting the passive transfer of contact sensitivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies / immunology*
  • Dermatitis, Contact / immunology*
  • Haptens / immunology*
  • Immune System / immunology
  • Lymphokines / immunology
  • Mice
  • Mice, Inbred C57BL
  • T-Lymphocytes, Regulatory / immunology*

Substances

  • Antibodies
  • Haptens
  • Lymphokines