Prostate cancer-associated lncRNAs

Cancer Lett. 2018 Apr 1:418:159-166. doi: 10.1016/j.canlet.2018.01.012. Epub 2018 Jan 9.

Abstract

Long non-coding RNA (LncRNA) is defined as an RNA transcript that does not encode any protein, with a length longer than 200 nt. Based on the recent advances in high-throughput sequencing techniques, a large number of lncRNAs have been characterized as functional transcripts that play important roles in various biological processes as well as pathologic states. In a research field of prostate cancer, several key lncRNAs have been identified as new players that contribute to the pathophysiology of the disease, which is primarily regulated by androgen and its cognate receptor. This review sheds light on the history and future perspective of these prostate cancer-associated lncRNAs.

Keywords: Androgen receptor; Castration-resistant prostate cancer; Long non-coding RNA; Prostate cancer; RNA biology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Gene Expression Regulation, Neoplastic*
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Male
  • Models, Genetic
  • Prostate / metabolism*
  • Prostate / pathology
  • Prostate / physiopathology
  • Prostatic Neoplasms / genetics*
  • Prostatic Neoplasms / metabolism
  • Prostatic Neoplasms / physiopathology
  • RNA, Long Noncoding / genetics*
  • RNA, Long Noncoding / metabolism
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism

Substances

  • RNA, Long Noncoding
  • RNA, Messenger