Abstract
Mycobacterium abscessus lung disease is difficult to treat due to inducible resistance to macrolides. However, 15%-20% of isolates are macrolide susceptible. In 14 patients with macrolide-susceptible M. abscessus lung disease, all isolates had nonfunctional erm(41) gene, and sputum culture conversion rate was achieved in 93% (13/14) following antibiotic therapy.
Keywords:
Drug resistance; Macrolides; Mycobacterium abscessus; Nontuberculous mycobacteria; Treatment.
Copyright © 2017 Elsevier Inc. All rights reserved.
MeSH terms
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Adult
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Aged
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use*
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Female
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Humans
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Macrolides / pharmacology
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Macrolides / therapeutic use*
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Male
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Methyltransferases / genetics
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Middle Aged
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Mutation
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Mycobacterium Infections, Nontuberculous / drug therapy*
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Mycobacterium Infections, Nontuberculous / microbiology
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Mycobacterium abscessus / drug effects
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Mycobacterium abscessus / genetics
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Mycobacterium abscessus / isolation & purification*
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Pneumonia, Bacterial / drug therapy*
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Pneumonia, Bacterial / microbiology
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Treatment Outcome
Substances
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Anti-Bacterial Agents
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Macrolides
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Methyltransferases
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rRNA (adenosine-O-2'-)methyltransferase