Autoantibodies are important indicators for the diagnosis of primary biliary cholangitis (PBC). The autoantibodies in PBC patients are mainly antimitochondrial antibodies (AMAs) and antinuclear antibodies (ANAs). AMAs are one of the diagnostic indices of PBC. PBC-specific ANAs (nuclear dots or nuclear envelope, anti-sp100, and anti-gp210) have a high specificity in the diagnosis of AMA-negative PBC. This article reviews the clinical significance of these autoantibodies and analyzes some misconceptions about the clinical diagnosis of AMA-negative PBC and PBC-AIH overlap syndrome.
自身抗体是诊断原发性胆汁性胆管炎（PBC）的重要指标。PBC患者的自身抗体主要有两类：抗线粒体抗体（AMA）和抗核抗体（ANA）。AMA是PBC诊断指标之一。PBC特异性抗核抗体（核点型或核周型ANA，抗-sp100和抗-gp210）对AMA阴性的PBC具有重要诊断作用。现综述这些自身抗体的临床意义，并对临床诊断AMA阴性PBC和PBC-自身免疫性肝炎重叠综合征的某些误解进行分析。.
Keywords: Autoantibodies; Diagnosis; Hepatitis, autoimmune; Primary biliary cholangitis.