Oleanane-type triterpenoid saponins from Lysimachia fortunei Maxim

Shu-Lin Zhang; Zi-Ni Yang; Cui He; Hai-Bing Liao; Heng-Shan Wang; Zhen-Feng Chen; Dong Liang

doi:10.1016/j.phytochem.2017.12.022

Oleanane-type triterpenoid saponins from Lysimachia fortunei Maxim

Phytochemistry. 2018 Mar:147:140-146. doi: 10.1016/j.phytochem.2017.12.022. Epub 2018 Jan 8.

Authors

Shu-Lin Zhang¹, Zi-Ni Yang¹, Cui He¹, Hai-Bing Liao², Heng-Shan Wang¹, Zhen-Feng Chen¹, Dong Liang³

Affiliations

¹ State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China.
² State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China. Electronic address: lhbing188@163.com.
³ State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China. Electronic address: liangdonggxnu@163.com.

PMID: 29324278
DOI: 10.1016/j.phytochem.2017.12.022

Abstract

Six previously undescribed oleanane-type triterpenoid saponins, fortunosides A-F, together with six known ones, were isolated from the aerial parts of Lysimachia fortunei Maxim. Their structures were established by spectroscopic data analyses (1D, 2D-NMR and HRESIMS) and chemical methods. All isolated triterpenoid saponins were evaluated for their cytotoxicity against four human liver cancer cell lines (SMMC-7721, Hep3B, HuH7, and SK-Hep-1). Three saponins with the aglycone protoprimulagenin A exhibited moderate cytotoxicity against all of the tested human cancer cell lines, with IC₅₀ values ranging from 4.76 to 15.12 μM.

Keywords: Cytotoxic activities; Lysimachia fortunei Maxim; Myrsinaceae; Triterpenoid saponins.

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
Cell Survival / drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Drugs, Chinese Herbal / chemistry*
Drugs, Chinese Herbal / isolation & purification
Drugs, Chinese Herbal / pharmacology
Humans
Medicine, Chinese Traditional
Molecular Structure
Oleanolic Acid / analogs & derivatives*
Oleanolic Acid / chemistry
Oleanolic Acid / isolation & purification
Oleanolic Acid / pharmacology
Plant Components, Aerial / chemistry*
Plants, Medicinal / chemistry
Primulaceae / chemistry*
Saponins / chemistry
Saponins / isolation & purification
Saponins / pharmacology*
Structure-Activity Relationship

Substances

Antineoplastic Agents, Phytogenic
Drugs, Chinese Herbal
Saponins
oleanane
Oleanolic Acid