Antimicrobial and antioxidant activities of two polyketides from lichen-endophytic fungus Preussia sp

Z Naturforsch C J Biosci. 2018 Feb 23;73(3-4):161-163. doi: 10.1515/znc-2017-0105.

Abstract

Two compounds, compounds 1 and 2, were isolated from Preussia sp. The molecular structures of both compounds were elucidated by analyzing one-dimensional (1D) and 2D nuclear magnetic resonance data along with high-resolution mass spectrometry data. Compound 1 was obtained as novel in structure, and compound 2 was recently reported elsewhere. Compound 1 did not show antioxidant and antimicrobial activities and brine shrimp toxicity, while compound 2 showed strong antioxidant activity (DPPH reduction capacity; IC50=3 μg/mL) and brine shrimp toxicity (LD50=50 μg/mL).

Keywords: Preussia sp; antioxidant; brine shrimp; endophyte; lichen.

MeSH terms

  • Anti-Infective Agents / chemistry*
  • Anti-Infective Agents / toxicity
  • Antioxidants / chemistry*
  • Antioxidants / toxicity
  • Ascomycota / chemistry*
  • Lichens / chemistry*
  • Polyketides / chemistry*
  • Polyketides / toxicity
  • Staphylococcus aureus / drug effects

Substances

  • Anti-Infective Agents
  • Antioxidants
  • Polyketides