Comparison of three prognostic models for predicting cancer-specific survival among patients with gastrointestinal stromal tumors

Future Oncol. 2018 Feb;14(4):379-389. doi: 10.2217/fon-2017-0450. Epub 2018 Jan 10.

Abstract

Aim: To evaluate the predictive value for cancer-specific survival of the models of the American Joint Committee on Cancer (AJCC) stage, NIH and Armed Forces Institute of Pathology (AFIP) among patients with gastrointestinal stromal tumors (GISTs).

Methods: Surveillance, Epidemiology and End Results database (2010-2014) was accessed. Overall survival analysis and adjusted cancer-specific Cox regression hazard was calculated.

Results: For gastric GISTs, concordance-index according to AJCC was 0.834; according to NIH was 0.833; according to AFIP was 0.836. Concordance-index for nongastric GISTs according to AJCC was 0.800, according to NIH was 0.801 and according to AFIP was 0.799.

Conclusion: The performance of the three models is comparable with regards to cancer-specific survival prediction.

Keywords: AFIP; AJCC; GIST; NIH; SEER.

MeSH terms

  • Adult
  • Aged
  • Disease-Free Survival
  • Female
  • Gastrointestinal Stromal Tumors / epidemiology*
  • Gastrointestinal Stromal Tumors / pathology
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / epidemiology*
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Staging
  • Prognosis*
  • SEER Program
  • Survival Analysis