Randomized Control Trial for Reduction of Body Weight, Body Fat Patterning, and Cardiometabolic Risk Factors in Overweight Worksite Employees in Delhi, India

J Diabetes Res. 2017:2017:7254174. doi: 10.1155/2017/7254174. Epub 2017 Nov 29.

Abstract

Background: We studied the impact of the multicomponent interventions on body weight and cardiometabolic risk factors in overweight individuals working in corporate worksites.

Methods: Overweight (BMI ≥ 23 kg/m2) subjects were recruited from four randomised worksites [two active intervention (n, recruited, 180, completed 156) and two control (n, recruited 130, completed 111)]. Intensive intervention was given at intervention worksite.

Results: High prevalence (%) of obesity (90.9, 80.2), abdominal obesity (93.5, 84.3), excess skinfold thickness (70.3, 75.9), and low high-density lipoprotein cholesterol (HDL-c) levels (56.8, 63.7) were seen in the intervention and the control group, respectively. At the end of intervention, the following significant changes were observed in the intervention group: decrease in weight, BMI, waist circumference, serum triglycerides, and increase in HDL-c. Weight loss of more than 5% was seen in 12% and 4% individuals in the intervention and control groups, respectively. Most importantly, the sum of all the skinfold measurements (mm) in the intervention group decreased significantly more than the control group (12.51 ± 10.38 versus 3.50 ± 8.18, resp.).

Conclusion: This multicomponent worksite trial showed a reduction in weight, excess subcutaneous fat, and cardiometabolic risk factors after 6 months of active intervention in overweight Asian Indians.

Trial registration: This trial is registered with NCT03249610.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Body Fat Distribution*
  • Body Weight
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / prevention & control*
  • Diet, Reducing
  • Employment
  • Female
  • Humans
  • India / epidemiology
  • Male
  • Metabolic Syndrome / etiology
  • Metabolic Syndrome / prevention & control*
  • Middle Aged
  • Obesity / complications
  • Obesity / epidemiology
  • Obesity / metabolism
  • Obesity / therapy
  • Overweight / complications
  • Overweight / epidemiology
  • Overweight / metabolism
  • Overweight / therapy*
  • Risk Factors
  • Risk Reduction Behavior
  • Weight Loss / physiology
  • Weight Reduction Programs* / methods
  • Workplace* / statistics & numerical data

Associated data

  • ClinicalTrials.gov/NCT03249610