Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells

PLoS One. 2018 Jan 9;13(1):e0190374. doi: 10.1371/journal.pone.0190374. eCollection 2018.

Abstract

Previously, quercetin has been reported to be a senolytic, a drug that selectively removes senescent cells, in HUVECs. However, we found neither quercetin nor Q3G was effective as a senolytic for adult human endothelial cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cell Proliferation / drug effects
  • Cellular Senescence / drug effects*
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / drug effects*
  • Female
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • Quercetin / analogs & derivatives*
  • Quercetin / pharmacology*

Substances

  • hyperoside
  • Quercetin