Enhanced Efflux Pump Activity in Old Candida glabrata Cells

Antimicrob Agents Chemother. 2018 Feb 23;62(3):e02227-17. doi: 10.1128/AAC.02227-17. Print 2018 Mar.

Abstract

We investigated the effect of replicative aging on antifungal resistance in Candida glabrata Our studies demonstrate significantly increased transcription of ABC transporters and efflux pump activity in old versus young C. glabrata cells of a fluconazole-sensitive and -resistant strain. In addition, higher tolerance to killing by micafungin and amphotericin B was noted and is associated with higher transcription of glucan synthase gene FKS1 and lower ergosterol content in older cells.

Keywords: Candida glabrata; aging; antifungal resistance; drug resistance mechanisms; efflux pumps.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • ATP-Binding Cassette Transporters / genetics*
  • ATP-Binding Cassette Transporters / metabolism
  • Amphotericin B / pharmacology
  • Antifungal Agents / pharmacology*
  • Biological Transport
  • Candida glabrata / drug effects*
  • Candida glabrata / genetics
  • Candida glabrata / growth & development
  • Candida glabrata / metabolism
  • Cell Division
  • Drug Resistance, Fungal / genetics
  • Ergosterol / metabolism
  • Fluconazole / pharmacology
  • Fungal Proteins / genetics*
  • Fungal Proteins / metabolism
  • Gene Expression Regulation, Fungal*
  • Genes, MDR*
  • Glucosyltransferases / genetics
  • Glucosyltransferases / metabolism
  • Micafungin / pharmacology
  • Microbial Sensitivity Tests

Substances

  • ATP-Binding Cassette Transporters
  • Antifungal Agents
  • Fungal Proteins
  • Amphotericin B
  • Fluconazole
  • Glucosyltransferases
  • glucan synthase
  • Micafungin
  • Ergosterol