Use of Polymer Inclusion Membranes (PIMs) as support for electromembrane extraction of non-steroidal anti-inflammatory drugs and highly polar acidic drugs

Román-Hidalgo Cristina; Martín-Valero María Jesús; Fernández-Torres Rut; Bello-López Miguel Ángel

doi:10.1016/j.talanta.2017.11.066

Use of Polymer Inclusion Membranes (PIMs) as support for electromembrane extraction of non-steroidal anti-inflammatory drugs and highly polar acidic drugs

Talanta. 2018 Mar 1:179:601-607. doi: 10.1016/j.talanta.2017.11.066. Epub 2017 Dec 2.

Authors

Román-Hidalgo Cristina¹, Martín-Valero María Jesús², Fernández-Torres Rut³, Bello-López Miguel Ángel⁴

Affiliations

¹ Department of Analytical Chemistry, Faculty of Chemistry, University of Sevilla, c/Prof. García González, s/n, 41012 Seville, Spain.
² Department of Analytical Chemistry, Faculty of Chemistry, University of Sevilla, c/Prof. García González, s/n, 41012 Seville, Spain. Electronic address: mmartin@us.es.
³ Department of Analytical Chemistry, Faculty of Chemistry, University of Sevilla, c/Prof. García González, s/n, 41012 Seville, Spain; Research Centre of Health and Environment (CYSMA), University of Huelva, Spain.
⁴ Department of Analytical Chemistry, Faculty of Chemistry, University of Sevilla, c/Prof. García González, s/n, 41012 Seville, Spain. Electronic address: mabello@us.es.

PMID: 29310282
DOI: 10.1016/j.talanta.2017.11.066

Abstract

The use of polymer inclusion membranes (PIMs) as support of 1-octanol liquid membrane in electromembrane extraction (EME) procedure is proposed. Synthesis of PIMs were optimized to a composition of 29% (w/w) of cellulose triacetate as base polymer and 71% (w/w) of Aliquat®336 as cationic carrier. Flat PIMs of 25µm thickness and 6mm diameter were used. EME protocol was implemented for the simultaneous extraction of four non-steroidal anti-inflammatory drugs (NSAIDs) (salicylic acid, ketoprofen, naproxen and ibuprofen) and four highly polar acidic drugs (anthranilic acid, nicotinic acid, amoxicillin and hippuric acid). Posterior HPLC separation of the extracted analytes was developed with diode array detection. Recoveries in the 81-34% range were obtained. EME procedure was applied to human urine samples.

Keywords: Electromembrane extraction; Non-steroidal anti-inflammatory drugs; PIM; Polar drugs; Polymer inclusion membranes.

MeSH terms

Amoxicillin / isolation & purification
Amoxicillin / urine
Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
Anti-Inflammatory Agents, Non-Steroidal / urine
Cellulose / analogs & derivatives*
Cellulose / chemistry
Electrochemical Techniques*
Hippurates / isolation & purification
Hippurates / urine
Ibuprofen / isolation & purification
Ibuprofen / urine
Ketoprofen / isolation & purification
Ketoprofen / urine
Membranes, Artificial
Naproxen / isolation & purification
Naproxen / urine
Niacin / isolation & purification
Niacin / urine
Quaternary Ammonium Compounds / chemistry*
Salicylic Acid / isolation & purification
Salicylic Acid / urine
ortho-Aminobenzoates / isolation & purification
ortho-Aminobenzoates / urine

Substances

Anti-Inflammatory Agents, Non-Steroidal
Hippurates
Membranes, Artificial
Quaternary Ammonium Compounds
ortho-Aminobenzoates
anthranilic acid
Niacin
trioctylmethylammonium
Naproxen
Amoxicillin
Cellulose
cellulose triacetate
Ketoprofen
Salicylic Acid
hippuric acid
Ibuprofen