Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on Pathological Methods and Prognostic Factors in Vestibular Schwannomas

Abstract

Target population: Adults diagnosed with vestibular schwannomas.

Question 1: What is the prognostic significance of Antoni A vs B histologic patterns in vestibular schwannomas?

Recommendation: No recommendations can be made due to a lack of adequate data.

Question 2: What is the prognostic significance of mitotic figures seen in vestibular schwannoma specimens?

Recommendation: No recommendations can be made due to a lack of adequate data.

Question 3: Are there other light microscopic features that predict clinical behavior of vestibular schwannomas?

Recommendation: No recommendations can be made due to a lack of adequate data.

Question 4: Does the KI-67 labeling index predict clinical behavior of vestibular schwannomas?

Recommendation: No recommendations can be made due to a lack of adequate data.

Question 5: Does the proliferating cell nuclear antigen labeling index predict clinical behavior of vestibular schwannomas?

Recommendation: No recommendations can be made due to a lack of adequate data.

Question 6: Does degree of vascular endothelial growth factor expression predict clinical behavior of vestibular schwannomas?

Recommendation: No recommendations can be made due to a lack of adequate data. The full guideline can be found at: https://www.cns.org/guidelines/guidelines-management-patients-vestibular-schwannoma/chapter_6.

Keywords: Acoustic neuroma; Histopathology; Pathology; Prognosis; Vestibular schwannoma.