Electrochemical antioxidant screening based on a chitosan hydrogel

Li Fu; Aiwu Wang; Fucong Lyv; Guosong Lai; Huaiwei Zhang; Jinhong Yu; Cheng-Te Lin; Aimin Yu; Weitao Su

doi:10.1016/j.bioelechem.2017.12.013

Electrochemical antioxidant screening based on a chitosan hydrogel

Bioelectrochemistry. 2018 Jun:121:7-10. doi: 10.1016/j.bioelechem.2017.12.013. Epub 2017 Dec 27.

Authors

Li Fu¹, Aiwu Wang², Fucong Lyv³, Guosong Lai⁴, Huaiwei Zhang⁵, Jinhong Yu⁶, Cheng-Te Lin⁶, Aimin Yu⁷, Weitao Su⁵

Affiliations

¹ Collage of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, PR China. Electronic address: fuli@hdu.edu.au.
² Center of Super-Diamond and Advanced Films (COSDAF), City University of Hong Kong, Hong Kong. Electronic address: awwang2-c@my.cityu.edu.hk.
³ Center of Super-Diamond and Advanced Films (COSDAF), City University of Hong Kong, Hong Kong.
⁴ Hubei Collaborative Innovation Center for Rare Metal Chemistry, Hubei Key Laboratory of Pollutant Analysis & Reuse Technology, Department of Chemistry, Hubei Normal University, Huangshi 435002, PR China.
⁵ Collage of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, PR China.
⁶ Key Laboratory of Marine New Materials and Related Technology, Zhejiang Key Laboratory of Marine Materials and Protection Technology, Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, PR China.
⁷ Hubei Collaborative Innovation Center for Rare Metal Chemistry, Hubei Key Laboratory of Pollutant Analysis & Reuse Technology, Department of Chemistry, Hubei Normal University, Huangshi 435002, PR China; Department of Chemistry and Biotechnology, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.

PMID: 29306186
DOI: 10.1016/j.bioelechem.2017.12.013

Abstract

A chitosan based hydrogel has been fabricated using silver ions as crosslinking agent. Silver redox behavior in the hydrogel is suppressed due to complexation. However, hydrogen peroxide induced hydroxyl radicals could attract the glucoside bonds and consequently restore silver redox behavior. Therefore, we used this hydroxyl radical induced chitos and epolymerization mechanism as an indicator for antioxidant capacity evaluation. Therefore, we used this hydroxyl radical induced chitos and epolymerization as an indicator for antioxidant capacity evaluation. Due to the low cost, portability and avoidance of the need for electrode modification, we believe the proposed hydrogel sensing platform shows great potential for antioxidant screening applications.

Keywords: Antioxidant; Depolymerization; Electrochemical sensing; Hydrogel; Hydroxyl radical.

MeSH terms

Antioxidants / pharmacology*
Ascorbic Acid / pharmacology*
Chitosan / chemistry*
Drug Evaluation, Preclinical / methods
Electrochemical Techniques / methods*
Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry*
Hydroxyl Radical / analysis*
Oxidation-Reduction / drug effects
Polymerization / drug effects
Silver / chemistry

Substances

Antioxidants
Hydrogel, Polyethylene Glycol Dimethacrylate
Hydroxyl Radical
Silver
Chitosan
Ascorbic Acid