Antiviral immunity backfires: Pathogenic effects of type I interferon signaling in fetal development

Sci Immunol. 2018 Jan 5;3(19):eaar3446. doi: 10.1126/sciimmunol.aar3446.

Authors

Rebecca L Casazza¹, Helen M Lazear²

Affiliations

¹ Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
² Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. helen.lazear@med.unc.edu.

PMID: 29305463
DOI: 10.1126/sciimmunol.aar3446

Abstract

Interferon-α/β signaling is pathogenic in a mouse model of congenital Zika virus infection.

Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Publication types

Review

MeSH terms

Animals
Antiviral Agents / immunology*
Fetal Development / immunology*
Fetal Diseases / immunology
Fetal Diseases / virology
Humans
Interferon Type I / immunology*
Signal Transduction / immunology
Zika Virus Infection / immunology*

Substances

Antiviral Agents
Interferon Type I