Developing T-cell therapies for lymphoma without receptor engineering

Blood Adv. 2017 Dec 8;1(26):2579-2590. doi: 10.1182/bloodadvances.2017009886. eCollection 2017 Dec 12.

Abstract

T-cell therapy has emerged from the bench for the treatment of patients with lymphoma. Responses to T-cell therapeutics are regulated by multiple factors, including the patient's immune system status and disease stage. Outside of engineering of chimeric antigen receptors and artificial T-cell receptors, T-cell therapy can be mediated by ex vivo expansion of antigen-specific T cells targeting viral and/or nonviral tumor-associated antigens. These approaches are contributing to enhanced clinical responses and overall survival. In this review, we summarize the available T-cell therapeutics beyond receptor engineering for the treatment of patients with lymphoma.

Publication types

  • Review