Severe reduction of free-form ADAMTS13, unbound to von Willebrand factor, in plasma of patients with HELLP syndrome

Yoko Yoshida; Masanori Matsumoto; Hideo Yagi; Ayami Isonishi; Kazuya Sakai; Masaki Hayakawa; Yuji Hori; Toshiyuki Sado; Hiroshi Kobayashi; Yoshihiro Fujimura

doi:10.1182/bloodadvances.2017006767

Severe reduction of free-form ADAMTS13, unbound to von Willebrand factor, in plasma of patients with HELLP syndrome

Blood Adv. 2017 Aug 23;1(20):1628-1631. doi: 10.1182/bloodadvances.2017006767. eCollection 2017 Sep 12.

Affiliations

¹ Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Japan.
² Japanese Red Cross Kinki Block Blood Center, Ibaraki, Japan; and.
³ Department of Obstetrics and Gynecology, Nara Medical University, Kashihara, Japan.

Abstract

Severely decreased ADAMTS13 unbound to VWF may play a key role in the pathogenesis of HELLP syndrome.A qualitative ADAMTS13 assay may be important for diagnosing HELLP syndrome.