Chromatin dynamics during the differentiation of long-term hematopoietic stem cells to multipotent progenitors

Xiang Yu; Chao Wu; Dheeraj Bhavanasi; Hong Wang; Brian D Gregory; Jian Huang

doi:10.1182/bloodadvances.2016003384

Chromatin dynamics during the differentiation of long-term hematopoietic stem cells to multipotent progenitors

Blood Adv. 2017 May 30;1(14):887-898. doi: 10.1182/bloodadvances.2016003384. eCollection 2017 Jun 13.

Authors

Xiang Yu¹, Chao Wu², Dheeraj Bhavanasi³, Hong Wang⁴, Brian D Gregory¹, Jian Huang²

Affiliations

¹ Department of Biology, University of Pennsylvania, Philadelphia, PA.
² Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA.
³ Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA; and.
⁴ Center for Metabolic Disease Research, Department of Pharmacology, Temple University Lewis Katz School of Medicine, Philadelphia, PA.

Abstract

ATAC-seq provides genome-wide chromatin state in 3 cell types of hematopoietic stem/progenitor cells.Transcription factor cohorts are associated with dynamic changes of open chromatin during the differentiation of LT/ST-HSCs to MPPs.

Grants and funding

R00 HL107747/HL/NHLBI NIH HHS/United States