Background: Gastrointestinal (GI) symptoms are common in the general population. This investigation studied the effects of Carthami flos (CF), a natural product, on GI motility.
Methods: We checked the intestinal transit rates (ITRs) or gastric emptying in normal and in GI-motility-dysfunction (GMD) mice in vivo. The GMD mice were made by acetic acid or streptozotocin.
Results: Both ITRs and gastric emptying were increased by CF (0.0025-0.25 g/kg) dose dependently. Also, in the GMD mice models, acetic-acid-induced peritoneal irritation, and streptozotocin-induced diabetic mice, the ITRs were decreased compared to normal mice, and these decreases were inhibited by CF.
Conclusion: These results suggest that CF is one of the good candidates for the development of a prokinetic agent that may regulate GI-motility functions.
Keywords: Carthami flos; GI-motility dysfunction; Gastric emptying; Gastrointestinal motility; Intestinal transit rate.