Multi-directional optical coherence tomography for retinal imaging

Biomed Opt Express. 2017 Nov 13;8(12):5560-5578. doi: 10.1364/BOE.8.005560. eCollection 2017 Dec 1.

Abstract

We introduce multi-directional optical coherence tomography (OCT), a technique for investigation of the scattering properties of directionally reflective tissue samples. By combining the concepts of multi-channel and directional OCT, this approach enables simultaneous acquisition of multiple reflectivity depth-scans probing a mutual sample location from differing angular orientations. The application of multi-directional OCT in retinal imaging allows for in-depth investigations on the directional reflectivity of the retinal nerve fiber layer, Henle's fiber layer and the photoreceptor layer. Major ophthalmic diseases (such as glaucoma or age-related macular degeneration) have been reported to alter the directional reflectivity properties of these retinal layers. Hence, the concept of multi-directional OCT might help to gain improved understanding of pathology development and progression. As a first step, we demonstrate the capabilities of multi-directional OCT in the eyes of healthy human volunteers.

Keywords: (110.4500) Optical coherence tomography; (170.0170) Medical optics and biotechnology; (170.4470) Ophthalmology.