Objective: To investigate the clinical effect and safety of electroencephalographic biofeedback therapy in improving memory disorders in patientsin the recovery stage of acute severe toxic encephalopathy. Methods: A total of 52 patients in the recovery stage of acute severe toxic encephalopathy who were hospitalized in our hospital from March 2013 to December 2016 were enrolled and randomly divided into observation group with 27 patients and control group with 25 patients. Both groups were given the drugs to promote the metabolism of brain cells,and the patients in the observation group were given electroencephalographic biofeedback therapy in addition. The Chinese revised version of Wechsler Memory Scale Type A was used to measure memory ability before and after each course of treatment. The treatment outcome was evaluated for both groups. Results: There were no significant differences in the scores of long-term memory,short-term memory, immediate memory, and memory quotient between the two groups before treatment(P>0.05).After the first course of treatment ended, the observation group had significant increases in the scores of forward task,backward task,association,and memory quotient(P<0.05); compared with the control group, the observation group had a significant reduction in the score of backward task(P<0.05).After the second course of treatmentended, the observation group had significant increases in the scores offorward task,backward task,memorization of pictures,reproduction,association,comprehension,and memory quotient,and the control group had significant increases in the scores of reproduction,association,comprehension,and memory quotient(P<0.05); compared with the control group, the observation group had significant increases in the scores of forward task,backward task,memorization of pictures, reproduction, association, comprehension, and memory quotient(P<0.05).Two patients experiencedchest distress, palpitation, and dysphoria during treatment, which did not affect the treatment. Conclusion: Electroencephalographic biofeedback therapy has a certain effect in the treatment of memory disorders in patients with acute severe toxic encephalopathy.
目的： 评价脑电生物反馈治疗对改善急性重度中毒性脑病恢复期患者记忆障碍的临床疗效和安全性。 方法： 选择2013年3月至2016年12月在我院住院的52例急性重度中毒性脑病恢复期患者，随机分为观察组（27例）和对照组（25例）。2组患者均予促脑细胞代谢药物对症治疗，观察组在此治疗基础上加用脑电生物反馈疗法。分别于每个疗程治疗前后使用中国修订甲式韦氏记忆量表（WMS-RC-甲式）测评患者记忆能力，评价2组患者的治疗效果。 结果： 治疗前2组患者的长时记忆、短时记忆、瞬时记忆以及记忆商值评分差异均无统计学意义（P>0.05）。观察组患者第1个疗程结束后顺数、倒数、联想、记忆商值评分均较治疗前明显增加，差异有统计学意义（P<0.05）；与对照组比较，观察组第1个疗程结束后倒数评分明显降低，差异有统计学意义（P<0.05）。第2个疗程结束后，观察组患者顺数、倒数、记图、再生、联想、理解、记忆商值评分均较治疗前明显增加，对照组再生、联想、理解、记忆商值评分均较治疗前明显增加，差异均有统计学意义（P<0.05）；与对照组比较，观察组患者第2个疗程结束后顺数、倒数、记图、再生、联想、理解、记忆商值评分均明显增加，差异有统计学意义（P<0.05）。2组患者治疗期间均有2例出现胸闷、心悸、烦躁症状，均未影响疗程。 结论： 脑电生物反馈疗法对改善急性重度中毒性脑病所致患者记忆障碍的康复有一定疗效。.
Keywords: Electroencephalographic biofeedback; Memory disorders; Toxic encephalopathy.