Enantioselective Total Synthesis of Cannabinoids-A Route for Analogue Development

Zachary P Shultz; Grant A Lawrence; Jeffrey M Jacobson; Emmanuel J Cruz; James W Leahy

doi:10.1021/acs.orglett.7b03668

Enantioselective Total Synthesis of Cannabinoids-A Route for Analogue Development

Org Lett. 2018 Jan 19;20(2):381-384. doi: 10.1021/acs.orglett.7b03668. Epub 2018 Jan 2.

Authors

Zachary P Shultz¹, Grant A Lawrence¹, Jeffrey M Jacobson¹, Emmanuel J Cruz¹, James W Leahy^{1

2

3}

Affiliations

¹ Department of Chemistry, University of South Florida , 4202 East Fowler Avenue, CHE 205, Tampa, Florida 33620, United States.
² Center for Drug Discovery and Innovation, University of South Florida , 3720 Spectrum Boulevard, Suite 303, Tampa, Florida 33612, United States.
³ Department of Molecular Medicine, Morsani College of Medicine, University of South Florida , MDC 7, 12901 Bruce B. Downs Boulevard, Tampa, Florida 33612, United States.

PMID: 29293352
DOI: 10.1021/acs.orglett.7b03668

Abstract

A practical synthetic approach to Δ⁹-tetrahydrocannabinol (1) and cannabidiol (2) that provides scalable access to these natural products and should enable the generation of novel synthetic analogues is reported.

Publication types

Research Support, Non-U.S. Gov't