Spiroorthoester group-containing pregnane glycosides from the root barks of Periploca chrysantha and their inhibitory activities against the proliferation of B and T lymphocytes

Bioorg Med Chem Lett. 2018 Feb 1;28(3):330-333. doi: 10.1016/j.bmcl.2017.12.045. Epub 2017 Dec 21.

Abstract

Phytochemical investigation of the root barks of Periploca chrysantha D. S. Yao, X. C. Chen et J. W. Ren (Asclepiadaceae) led to the elucidation of four new spiroorthoester group-containing pregnane glycosides (1-4), named periplosides W-Y and 3-O-formyl-periploside F. Their structures were elucidated on the basis of extensive spectroscopic analysis. The four new pregnane glycosides (1-4) were found to exhibit significantly inhibitory activities against the proliferation of B and T lymphocytes and favorable selective index comparable to those of cyclosporin A.

Keywords: Immunosuppression; Periploca chrysantha; Pregnane glycosides; Spiroorthoester group.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • B-Lymphocytes / drug effects*
  • Cell Proliferation / drug effects
  • Dose-Response Relationship, Drug
  • Glycosides / chemistry
  • Glycosides / pharmacology*
  • Humans
  • Molecular Conformation
  • Periploca / chemistry*
  • Plant Bark / chemistry*
  • Plant Roots / chemistry*
  • Pregnanes / chemistry
  • Pregnanes / pharmacology*
  • Spiro Compounds / chemical synthesis
  • Spiro Compounds / chemistry
  • Spiro Compounds / pharmacology*
  • Structure-Activity Relationship
  • T-Lymphocytes / drug effects*

Substances

  • Glycosides
  • Pregnanes
  • Spiro Compounds
  • pregnane glycoside