Diamond anvil cell (DAC) technique is widely employed for the high pressure measurements in the field of physics, chemistry, and material research. The new designs of DAC and new techniques for applying pressure have been gradually developed. This paper introduces a piezoelectric driving DAC device to achieve tunable high pressure at low temperature down to 20 K by in situ continuous pressure tuning. The tuning range is about 2-4 GPa depending on the applied electric voltage to piezoelectric lead zirconic titanate ceramic stack. The DAC device is well compatible with the cold chamber of a low temperature cryostat due to its small size and the convenient operation.