Breast cancer: Lesser-known facets and hypotheses

Biomed Pharmacother. 2018 Feb:98:499-506. doi: 10.1016/j.biopha.2017.12.087. Epub 2017 Dec 27.

Abstract

Breast cancer is the most common cancer in females. The deteriorating environment, and lifestyle flaws are raising the frequency of this cancer. Existing therapies are not universally-effective, and they cause side effects, relapses, and high mortality rate. Alternative medications may be milder, but are less effective or are inadequate for a complex disease like the breast cancer. So, it requires the understanding that drugs are not the solution of this cancer, but prevention is the sustainable solution. In the past decades, an enormous quantum of insights on this disease has been obtained. A lifestyle based on the template of estrogenic compounds and, the resultant endocrine disruption, and acidosis, is elevating aromatase level, promoting the deleterious forms of estrogen, and inducing epithelial proliferation. This review provids a holistic account of breast cancer as a inflammatory endocrinopathy, and how it can be curbed by discipline, and awareness.

Keywords: Breast cancer; Endocrine disruption; Estrogenic; Inflammations; Lifestyle revision.

Publication types

  • Review

MeSH terms

  • Animals
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / etiology
  • Breast Neoplasms / pathology*
  • Complementary Therapies / methods
  • Estrogens / therapeutic use
  • Female
  • Humans
  • Life Style
  • Selective Estrogen Receptor Modulators / therapeutic use

Substances

  • Estrogens
  • Selective Estrogen Receptor Modulators