Medium-term outcomes of 78,808 patients after heart valve surgery in a middle-income country: a nationwide population-based study

BMC Cardiovasc Disord. 2017 Dec 28;17(1):302. doi: 10.1186/s12872-017-0725-9.

Abstract

Background: Heart valve surgery outcomes are unknown in middle-income countries and thus cannot be used in health system decision making processes. This study estimated in-hospital mortality and medium and long-term survival.

Methods: This was a retrospective study of 78,806 patients who underwent heart valve surgery between 2001 and 2007 in Brazil. Two national databases were used, the Hospital Information System and the Mortality Information System. Kaplan-Meier survival analysis and log-rank tests were performed. Maximum and median follow-up was 7.7 and 2.8 years, respectively (0.002-7.707).

Results: Valve replacement accounted for 69.1% of procedures performed. Mitral stenosis, the most common valve injury, represented 38.9% of the total. In 94.7% of mitral stenosis patients, aetiology was rheumatic heart disease. In-hospital mortality was 7.6% and was higher for women, for patients who had undergone concomitant coronary artery bypass grafting (CABG) and for the elderly. Overall survival was 69.9% at the end of follow-up. Survival was worst among elderly, male and concomitant CABG patients (P<0.001).

Conclusions: Rheumatic heart disease is still a major public health problem in Brazil. In-hospital mortality and global survival rates of patients who have undergone heart valve surgery were less satisfactory than those reported in high-income countries. The findings of this study can contribute to guiding decision making processes in middle-income countries similar to Brazil and others concerned with improving the quality of care.

Keywords: Annular repair, cardiac valve; Brazil; Cardiac surgical procedures; Heart valve diseases; Hospital mortality; Medical record linkage; Rheumatic heart disease; Survival analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Brazil / epidemiology
  • Cardiac Surgical Procedures* / adverse effects
  • Cardiac Surgical Procedures* / mortality
  • Comorbidity
  • Coronary Artery Bypass / adverse effects
  • Coronary Artery Bypass / mortality
  • Coronary Artery Disease / mortality
  • Coronary Artery Disease / surgery
  • Female
  • Health Care Surveys
  • Heart Valve Diseases / diagnosis
  • Heart Valve Diseases / mortality
  • Heart Valve Diseases / surgery*
  • Heart Valves / surgery*
  • Hospital Mortality
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Proportional Hazards Models
  • Retrospective Studies
  • Rheumatic Heart Disease / diagnosis
  • Rheumatic Heart Disease / mortality
  • Rheumatic Heart Disease / surgery*
  • Risk Factors
  • Sex Factors
  • Time Factors
  • Treatment Outcome
  • Young Adult