A pro-inflammatory role of Fcα/μR on marginal zone B cells in sepsis

Akira Shibuya; Shin-Ichiro Honda; Kazuko Shibuya

doi:10.1093/intimm/dxx059

A pro-inflammatory role of Fcα/μR on marginal zone B cells in sepsis

Int Immunol. 2017 Dec 30;29(11):519-524. doi: 10.1093/intimm/dxx059.

Authors

Akira Shibuya¹, Shin-Ichiro Honda¹, Kazuko Shibuya¹

Affiliation

¹ Department of Immunology, Life Science Center of Tsukuba Advanced Research Alliance (TARA) and Faculty of Medicine, University of Tsukuba, Ten-nodai, Tsukuba, Ibaraki, Japan.

PMID: 29281010
DOI: 10.1093/intimm/dxx059

Abstract

Fc receptors play important roles for a wide array of immune responses. In contrast to the well-defined Fcγ and Fcε receptors, the molecular and functional characteristics of Fc receptors for IgA and IgM have remained incompletely understood for years. Recent progress has unveiled the characteristics of Fc receptors for IgA and IgM, including Fcα/μ receptor (Fcα/μR) (CD351), polymeric immunoglobulin receptor (poly-IgR), Fcα receptor (FcαRI) (CD89) and Fcμ receptor (FcμR). In this review, we summarize the molecular and functional characteristics of Fcα/μR in comparison with poly-IgR, FcμR and FcαRI, and focus particularly on the pro-inflammatory function of Fcα/μR expressed on marginal zone B cells in sepsis.

Keywords: Toll-like receptor 4; antibody therapy; endotoxic shock; interleukin-6.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
B-Lymphocytes / immunology*
Humans
Inflammation / immunology*
Receptors, Fc / immunology*
Receptors, Opioid, mu / immunology*
Sepsis / immunology*

Substances

Receptors, Fc
Receptors, Opioid, mu