Germacrane-Type Sesquiterpenoids with Antiproliferative Activities from Eupatorium chinense

J Nat Prod. 2018 Jan 26;81(1):85-91. doi: 10.1021/acs.jnatprod.7b00693. Epub 2017 Dec 27.

Abstract

Ten new germacrane-type sesquiterpenoids (1-10) were isolated from a whole plant extract of Eupatorium chinense. The structures were elucidated by analysis of their NMR and MS data as well as by comparison with literature values. The absolute configuration of eupachinsin A (1) was determined by single-crystal X-ray diffraction analysis. Compounds 3 and 4 exhibited cytotoxicity against a human breast cancer cell line (MDA-MB-231), with IC50 values of 0.8 and 3.4 μM, respectively. In addition, compounds 3-5 showed cytotoxicity against the human hepatocellular carcinoma cell line (HepG2), with IC50 values ranging from 3.6 to 7.6 μM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Breast Neoplasms / drug therapy
  • Carcinoma, Hepatocellular / drug therapy
  • Cell Line, Tumor
  • Cell Proliferation / drug effects*
  • Crystallography, X-Ray / methods
  • Cytotoxins / chemistry
  • Cytotoxins / pharmacology
  • Eupatorium / chemistry*
  • Female
  • Hep G2 Cells
  • Humans
  • Liver Neoplasms / drug therapy
  • Magnetic Resonance Spectroscopy / methods
  • Nasopharyngeal Carcinoma / drug therapy
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Sesquiterpenes, Germacrane / chemistry*
  • Sesquiterpenes, Germacrane / pharmacology*

Substances

  • Antineoplastic Agents, Phytogenic
  • Cytotoxins
  • Plant Extracts
  • Sesquiterpenes, Germacrane