Viral metagenomics, protein structure, and reverse genetics: Key strategies for investigating coronaviruses

Bryan A Johnson; Rachel L Graham; Vineet D Menachery

doi:10.1016/j.virol.2017.12.009

Viral metagenomics, protein structure, and reverse genetics: Key strategies for investigating coronaviruses

Virology. 2018 Apr:517:30-37. doi: 10.1016/j.virol.2017.12.009. Epub 2017 Dec 24.

Authors

Bryan A Johnson¹, Rachel L Graham², Vineet D Menachery³

Affiliations

¹ Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
² Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
³ Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: Vimenach@utmb.edu.

Abstract

Viral metagenomics, modeling of protein structure, and manipulation of viral genetics are key approaches that have laid the foundations of our understanding of coronavirus biology. In this review, we discuss the major advances each method has provided and discuss how future studies should leverage these strategies synergistically to answer novel questions.

Viral metagenomics, protein structure, and reverse genetics: Key strategies for investigating coronaviruses

Authors

Affiliations

Abstract

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