Progress in pharmacological research of chemokine like factor 1 (CKLF1)

Cytokine. 2018 Feb:102:41-50. doi: 10.1016/j.cyto.2017.12.002. Epub 2017 Dec 21.

Abstract

Currently, the research of chemokines has penetrated into many fields of life science. A new kind of chemokines, chemokine like factor 1 (CKLF1), which is cloned through suppression subtractive hybridisation (SSH) technology is expressed widely in human body, especially in the lung and peripheral blood leukocytes. CKLF1 has a broad spectrum of chemotaxic activity for many cells, such as lymphocytes, macrophages, bone marrow cells, nerve cells and so on. In addition, CKLF1 also stimulates the regeneration of skeletal muscle cells in vivo. Collecting data derived from our and other laboratories show that CKLF1 has an important relationship with allergic diseases, autoimmune diseases, tumors, cardio-cerebrovascular diseases and so on. Therefore, there be an important theoretical purport and applied value to make a summary of pharmacological progress of CKLF1.

Keywords: Allergic diseases; Autoimmune diseases; C19 peptide; C27 peptide; CCR4; Chemokine like factor 1.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases
  • Cardiovascular Diseases / immunology
  • Chemokines* / genetics
  • Chemokines* / immunology
  • Chemokines* / isolation & purification
  • Chemokines* / pharmacology
  • Chemotaxis
  • Humans
  • Hypersensitivity
  • MARVEL Domain-Containing Proteins* / genetics
  • MARVEL Domain-Containing Proteins* / immunology
  • MARVEL Domain-Containing Proteins* / isolation & purification
  • MARVEL Domain-Containing Proteins* / pharmacology
  • Neoplasms / immunology

Substances

  • CKLF protein, human
  • Chemokines
  • MARVEL Domain-Containing Proteins