The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosis

Daan Caudri; Lidija Turkovic; Jolyn Ng; Nicholas H de Klerk; Tim Rosenow; Graham L Hall; Sarath C Ranganathan; Peter D Sly; Stephen M Stick; AREST CF

doi:10.1016/j.jcf.2017.12.002

The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosis

J Cyst Fibros. 2018 Jul;17(4):462-469. doi: 10.1016/j.jcf.2017.12.002. Epub 2017 Dec 21.

Authors

Daan Caudri¹, Lidija Turkovic², Jolyn Ng², Nicholas H de Klerk², Tim Rosenow², Graham L Hall³, Sarath C Ranganathan⁴, Peter D Sly⁵, Stephen M Stick⁶; AREST CF

Affiliations

¹ Telethon Kids Institute, Perth, Australia; Dept. of Respiratory Medicine, Princess Margaret Hospital, Perth, Australia; Dept. of Pediatrics/Respiratory Medicine, Erasmus MC, Rotterdam, The Netherlands. Electronic address: daan.caudri@telethonkids.org.au.
² Telethon Kids Institute, Perth, Australia.
³ Telethon Kids Institute, Perth, Australia; Centre of Child Health Research, The University of Western Australia, Perth, Australia; School of Physiotherapy and Exercise Science, Curtin University, Australia.
⁴ Murdoch Childrens Research Institute, Parkville, Australia; Department of Respiratory and Sleep Medicine, Royal Children's Hospital, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia.
⁵ Child Health Research Centre, The University of Queensland, Brisbane, Australia.
⁶ Telethon Kids Institute, Perth, Australia; Dept. of Respiratory Medicine, Princess Margaret Hospital, Perth, Australia.

PMID: 29274943
DOI: 10.1016/j.jcf.2017.12.002

Abstract

Background: Staphylococcus aureus (S. aureus) may be related to more rapid progression of cystic fibrosis (CF) lung disease.

Methods: In the AREST CF cohort study, children diagnosed with CF undergo annual bronchoscopies with bronchoalveolar lavage and ultra-low-dose, chest computed tomography (CT) up to 6-years-old. Spirometry was assessed 3-monthly from the age of 4years. Associations between de novo S. aureus acquisition before school age and CT and lung function at ages 5-7years were investigated. Models were adjusted for multiple markers of disease severity at baseline.

Results: De novo S. aureus acquisition at 3-years-old (n/N=12/122) was associated with increased bronchiectasis score at age 5-6years. This association decreased but remained significant after adjustment for confounders. S. aureus at 3 was associated with significantly reduced FEF_25-75 at age 5-7years, but not with FEV₁-%-predicted.

Conclusion: De novo S. aureus acquisition at age 3 is associated with later bronchiectasis and FEF_25-75 in children with CF.

Keywords: CT scan; Infection and inflammation; Lung function; Structural lung damage.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Australia / epidemiology
Bronchiectasis* / diagnosis
Bronchiectasis* / etiology
Bronchiectasis* / physiopathology
Bronchoalveolar Lavage / methods*
Child
Child, Preschool
Cohort Studies
Cystic Fibrosis* / complications
Cystic Fibrosis* / diagnosis
Cystic Fibrosis* / epidemiology
Cystic Fibrosis* / microbiology
Disease Progression
Female
Humans
Lung* / microbiology
Lung* / pathology
Lung* / physiopathology
Male
Respiratory Function Tests / methods
Staphylococcal Infections* / complications
Staphylococcal Infections* / diagnosis
Staphylococcus aureus / isolation & purification*
Time Factors
Tomography, X-Ray Computed / methods