miRNA delivery for skin wound healing

Zhao Meng; Dezhong Zhou; Yongsheng Gao; Ming Zeng; Wenxin Wang

doi:10.1016/j.addr.2017.12.011

miRNA delivery for skin wound healing

Adv Drug Deliv Rev. 2018 Apr:129:308-318. doi: 10.1016/j.addr.2017.12.011. Epub 2017 Dec 19.

Authors

Zhao Meng¹, Dezhong Zhou², Yongsheng Gao¹, Ming Zeng¹, Wenxin Wang³

Affiliations

¹ Charles Institute of Dermatology, School of Medicine, University College Dublin, Dublin 4, Ireland.
² Charles Institute of Dermatology, School of Medicine, University College Dublin, Dublin 4, Ireland. Electronic address: dezhong.zhou@ucd.ie.
³ Charles Institute of Dermatology, School of Medicine, University College Dublin, Dublin 4, Ireland. Electronic address: wenxin.wang@tju.edu.cn.

PMID: 29273517
DOI: 10.1016/j.addr.2017.12.011

Abstract

The wound healing has remained a worldwide challenge as one of significant public health problems. Pathological scars and chronic wounds caused by injury, aging or diabetes lead to impaired tissue repair and regeneration. Due to the unique biological wound environment, the wound healing is a highly complicated process, efficient and targeted treatments are still lacking. Hence, research-driven to discover more efficient therapeutics is a highly urgent demand. Recently, the research results have revealed that microRNA (miRNA) is a promising tool in therapeutic and diagnostic fields because miRNA is an essential regulator in cellular physiology and pathology. Therefore, new technologies for wound healing based on miRNA have been developed and miRNA delivery has become a significant research topic in the field of gene delivery.

Keywords: Cutaneous wound healing; MicroRNA; Non-viral delivery; Scarring.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Gene Transfer Techniques*
Genetic Therapy*
Humans
MicroRNAs / genetics*
Wound Healing / genetics*

Substances

MicroRNAs