Chromanopyrones and a flavone from Hypericum monogynum

Fitoterapia. 2018 Mar:125:59-64. doi: 10.1016/j.fitote.2017.12.013. Epub 2017 Dec 18.

Abstract

Six new compounds, including three pyrone derivatives (2-4), one new flavone (5), and two new naturally-occurring compounds (1 and 6), together with 16 known compounds were isolated from the leaves and twigs of Hypericum monogynum. In addition, compounds 2-4 are racemates. Their structures and absolute configurations were determined on the basis of extensive analysis of spectroscopic data and ECD calculation. All compounds were evaluated for the inhibitory effects on α-glucosidase, compounds 1, 5, and 7 showed moderate inhibitory activities with IC50 values of 161.46, 257.78, and 11.54μg/ml, respectively. Compound 8 exhibited weak anti-oxidant activity with IC50 value of 12.55μg/ml.

Keywords: Anti-oxidant activity; Hypericum monogynum; Inhibitory effects on α-glucosidase; Pyrone derivatives.

MeSH terms

  • Antioxidants / isolation & purification
  • Flavones / isolation & purification*
  • Glycoside Hydrolase Inhibitors / isolation & purification
  • Hypericum / chemistry*
  • Molecular Structure
  • Plant Leaves / chemistry
  • Pyrones / isolation & purification*
  • alpha-Glucosidases

Substances

  • Antioxidants
  • Flavones
  • Glycoside Hydrolase Inhibitors
  • Pyrones
  • alpha-Glucosidases