Maternal and neonatal vitamin D deficiency and transient tachypnea of the newborn in full term neonates

J Perinat Med. 2018 Nov 27;46(9):1057-1060. doi: 10.1515/jpm-2017-0280.

Abstract

Aim: To investigate the association between maternal and neonatal serum 25-hydroxyvitamin D (25-OHD) levels and development of transient tachypnea of the newborn (TTN) in full term infants.

Methods: This was a prospective case-control study carried out on 30 neonates with TTN and their mothers and 30 control neonates and their mothers. Levels of 25-OHD were measured in maternal and neonatal blood samples that were obtained in the first 12-24 h of postnatal age.

Results: Both maternal and neonatal 25-OHD levels in the TTN group were significantly lower compared to the control group (P=0.0001). A negative correlation was observed between neonatal 25-OHD level and average hospital stay (P=0.0001).

Conclusion: We observed that lower maternal and neonatal vitamin 25-OHD levels were associated with TTN development in full term infants.

Keywords: 25-Hydroxyvitamin D; maternal; neonatal; transient tachypnea of the newborn; vitamin D deficiency.

MeSH terms

  • Adult
  • Case-Control Studies
  • Correlation of Data
  • Egypt
  • Female
  • Humans
  • Infant, Newborn
  • Male
  • Pregnancy
  • Pregnancy Complications / blood*
  • Prospective Studies
  • Transient Tachypnea of the Newborn* / blood
  • Transient Tachypnea of the Newborn* / diagnosis
  • Transient Tachypnea of the Newborn* / etiology
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood
  • Vitamin D Deficiency* / blood
  • Vitamin D Deficiency* / complications

Substances

  • Vitamin D
  • 25-hydroxyvitamin D