Benefits of non-surgical periodontal treatment in patients with type 2 diabetes mellitus and chronic periodontitis: A randomized controlled trial

J Clin Periodontol. 2018 Mar;45(3):345-353. doi: 10.1111/jcpe.12858. Epub 2018 Jan 19.

Abstract

Background: Periodontitis and diabetes are highly prevalent conditions whose association has long been recognized.

Objective: To evaluate the effect of non-surgical periodontal treatment on serum HbA1c (haemoglobin A1c or glycated haemoglobin) levels in patients with type 2 diabetes.

Research design and methods: This was a 6-month, single-masked, randomized clinical trial based on 90 patients (HbA1c: 7.7% (61 mmol/mol) ± 1.13%) who were randomly assigned to either the treatment group (oral hygiene instructions + scaling and root planing using ultrasound and Gracey curettes) or the control group (oral hygiene instructions + supragingival removal of plaque and calculus using ultrasound). Pocket depth, gingival index, and plaque index were assessed at baseline and after 3 and 6 months together with determinations of fasting plasma glucose, HbA1c, and bacterial counts.

Results: Treatment significantly improved the periodontal and metabolic parameters (p < .05), whereas in the control group no improvement was observed. These results were consistent with the bacteriological results in most but not all cases.

Conclusion: Non-surgical periodontal treatment resulted in a better glycaemic status of type 2 diabetes patients and demonstrated the importance of oral health in their general health.

Keywords: PCR; glycosylated haemoglobin; periodontal disease; scaling and root planing; type 2 diabetes mellitus.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Chronic Periodontitis / blood
  • Chronic Periodontitis / complications
  • Chronic Periodontitis / therapy*
  • Dental Plaque / microbiology
  • Dental Plaque / therapy
  • Dental Plaque Index
  • Dental Scaling*
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / complications*
  • Female
  • Glycated Hemoglobin / analysis*
  • Humans
  • Male
  • Middle Aged
  • Oral Hygiene
  • Periodontal Index
  • Real-Time Polymerase Chain Reaction
  • Root Planing*
  • Single-Blind Method

Substances

  • Glycated Hemoglobin A