One-pot exfoliation, functionalization, and size manipulation of graphene sheets: efficient system for biomedical applications

Lasers Med Sci. 2018 May;33(4):795-802. doi: 10.1007/s10103-017-2422-4. Epub 2017 Dec 21.

Abstract

In this work, we reported a facile method to produce stable aqueous graphene dispersion through direct exfoliation of graphite by modified hyperbranched polyglycerol. Size of graphene sheets was manipulated by simultaneous exfoliation and sonication of graphite, and functionalized graphene sheets with narrow size distribution were obtained. The polyglycerol-functionalized graphene sheets exhibited highly efficient cellular uptake and photothermal conversion, enabling it to serve as a photothermal agent for cancer therapy.

Keywords: Exfoliation; Graphene; Graphite; Photothermal therapy; Polyglycerol.

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Cell Survival / drug effects
  • Drug Screening Assays, Antitumor
  • Graphite / chemistry*
  • Graphite / pharmacology
  • Humans
  • Infrared Rays
  • Lasers
  • MCF-7 Cells
  • Particle Size
  • Photochemical Processes

Substances

  • Antineoplastic Agents
  • Graphite