Flumazenil

Excerpt

Flumazenil is a benzodiazepine antagonist typically used in overdose emergencies. The primary FDA-approved clinical uses for flumazenil include reversal agents for benzodiazepine overdose and postoperative sedation from benzodiazepine anesthetics. Flumazenil injection is indicated for a complete or partial reversal of the sedative effects of benzodiazepines in conscious sedation and general anesthesia in adult and pediatric populations. This activity focuses on the indications, mechanism of action, dosing, significant adverse effects, contraindications, monitoring, and toxicity of flumazenil so clinicians can direct patient therapy for optimal outcomes in benzodiazepine reversal. Empowering clinicians with the necessary knowledge and skills to navigate flumazenil therapy is paramount.