(off)Targeting UPR signaling: the race toward intervening ER proteostasis

Expert Opin Ther Targets. 2018 Feb;22(2):97-100. doi: 10.1080/14728222.2018.1420169. Epub 2017 Dec 23.

Rodrigo Pérez-Arancibia^{1

2

3

4}, Alexis Rivas^{1

2

3}, Claudio Hetz^{1

2

3

5

6}

¹ a Biomedical Neuroscience Institute, Faculty of Medicine, Universidad de Chile , Santiago , Chile.
² b Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile , Santiago , Chile.
³ c Center for Geroscience, Brain Health and Metabolism , Santiago , Chile.
⁴ d Department of Pharacologic Chemistry and Toxicology, Faculty of Chemical and Pharmaceutical Sciences , Natural Products Laboratory, Universidad de Chile , Santiago , Chile.
⁵ e Department of Immunology and Infectious diseases , Harvard School of Public Health , Boston , MA , USA.
⁶ f Buck Institute for Research on Aging , Novato , CA , USA.

No abstract available

Keywords: ER stress; IRE1; PERK; eIF2alpha; protein misfolding; proteostasis.

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