Dataset on the activation of Müller cells through macrophages upon hypoxia in the retina

Christina Nürnberg; Norbert Kociok; Claudia Brockmann; Timo Lischke; Sergio Crespo-Garcia; Nadine Reichhart; Susanne Wolf; Ria Baumgrass; Sabine A Eming; Sandra Beer-Hammer; Antonia M Joussen

doi:10.1016/j.dib.2017.11.062

Dataset on the activation of Müller cells through macrophages upon hypoxia in the retina

Data Brief. 2017 Nov 22:16:489-500. doi: 10.1016/j.dib.2017.11.062. eCollection 2018 Feb.

Affiliations

¹ Department of Ophthalmology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
² German Rheumatism Research Center Berlin, a Leibniz Institute, Berlin, Germany.
³ Department of Cellular Neuroscience, Max Delbrück Center in the Helmholtz Society, Berlin, Germany.
⁴ Department of Dermatology, University of Cologne, Germany.
⁵ Department of Pharmacology and Experimental Therapy and Interfaculty Center of Pharmacogenomics and Drug Research, University of Tübingen, Germany.

Abstract

The dataset presented in this article complements the article entitled "Myeloid cells contribute indirectly to VEGF expression upon hypoxia via activation of Müller cells" (C. Nürnberg, N. Kociok, C. Brockmann, T. Lischke, S. Crespo-Garcia, N. Reichhart, S. Wolf, R. Baumgrass, S.A. Eming, S. Beer-Hammer, and A.M. Joussen). This complementary dataset provides further insight into the experimental validation of the VEGF^fl/fl LysMCre (here named VEGF^mcko) knockout model used in the main article through genomic and quantitative Real-Time PCR in various murine tissues as well as additional flow cytometry data and immunohistochemical stainings. By providing these data, we aim to enable researcher to reproduce and critically analyze our data.