Study on expression of p16 and human papillomavirus 16 and 18 (E6) in OLP and its malignant transformation

Ting Liu; Hong Zhang; Xuesong Yang; Xiaojie Li; Yi Shi; Weidong Niu; Tingjiao Liu

doi:10.1016/j.prp.2017.09.014

Study on expression of p16 and human papillomavirus 16 and 18 (E6) in OLP and its malignant transformation

Pathol Res Pract. 2018 Feb;214(2):296-302. doi: 10.1016/j.prp.2017.09.014. Epub 2017 Nov 10.

Authors

Ting Liu¹, Hong Zhang², Xuesong Yang³, Xiaojie Li⁴, Yi Shi⁵, Weidong Niu⁴, Tingjiao Liu⁶

Affiliations

¹ College of Stomatology, Dalian Medical University, Dalian Medical University, Dalian, China; Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.
² College of Stomatology, Dalian Medical University, Dalian Medical University, Dalian, China; The First Affiliated Hospital, Dalian Medical University, Dalian, China.
³ Department of Biochemistry and Molecular Biology, Liaoning Provincial Core Lab of Glycobiology and Glycoengineering, Dalian Medical University, China.
⁴ College of Stomatology, Dalian Medical University, Dalian Medical University, Dalian, China.
⁵ West China School of Stomatology, Sichuan University, China.
⁶ College of Stomatology, Dalian Medical University, Dalian Medical University, Dalian, China. Electronic address: tingjiao@dlmedu.edu.cn.

PMID: 29254790
DOI: 10.1016/j.prp.2017.09.014

Abstract

Objective: The aim of this study is to investigate the expressions of p16 and HPV16/18(E6) in oral lichen planus (OLP) and malignant transformed OLP (MT-OLP).

Study design: The expression of p16 and HPV16/18(E6) in 40 cases of OLP and 6 MT-OLP was assessed by immunohistochemical staining. Twenty four cases of normal oral mucosa were used as controls.

Results: Compared to normal oral mucosa, the expression of p16 and HPV16/18(E6) protein increased in OLP and MT-OLP. And there was a correlation between p16 expression and HPV infection in OLP and OLP malignant lesions (p < 0.0001).

Conclusions: The expression of p16 protein might predict HPV16/18 infection in OLP. And HPV16/18(E6) infection might contribute to OLP malignant transformation.

Keywords: HPV 16/18; Lichen planus; Malignant transformation; p16.

MeSH terms

Adult
Carcinogenesis / pathology
Carcinoma, Squamous Cell / pathology
Carcinoma, Squamous Cell / virology*
Cell Transformation, Neoplastic / pathology
Female
Humans
Male
Middle Aged
Mouth Neoplasms / pathology
Mouth Neoplasms / virology*
Papillomaviridae / isolation & purification*
Papillomavirus Infections / pathology*
Papillomavirus Infections / virology