Abstract
E-cadherin, β-catenin and Snail are important molecules involved in cellular adhesion and epithelial-mesenchymal transition. Loss of E-cadherin expression, nuclear relocation of β-catenin and high expression of Snail are connected to tumor progression, rapid cell growth and metastasis. The aim of our study was to analyze the immunohistochemical expression of β-catenin, E-cadherin and Snail, depending on clinico-morphological aspects of the laryngeal squamous cell carcinomas. Our results revealed variable E-cadherin, β-catenin and Snail expression, depending on differentiation degree and tumor stage. These markers can be helpful in identifying the aggressive laryngeal squamous carcinomas.
MeSH terms
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Antigens, CD
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Cadherins / biosynthesis*
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Cadherins / genetics
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Carcinoma, Squamous Cell / genetics
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Carcinoma, Squamous Cell / metabolism*
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Carcinoma, Squamous Cell / pathology
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Female
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Head and Neck Neoplasms / genetics
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Head and Neck Neoplasms / metabolism*
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Head and Neck Neoplasms / pathology
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Humans
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Immunohistochemistry
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Laryngeal Neoplasms / genetics
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Laryngeal Neoplasms / metabolism*
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Laryngeal Neoplasms / pathology
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Male
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Middle Aged
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Neoplasm Staging
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Prognosis
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Snail Family Transcription Factors / biosynthesis*
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Snail Family Transcription Factors / genetics
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Squamous Cell Carcinoma of Head and Neck
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beta Catenin / biosynthesis*
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beta Catenin / genetics
Substances
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Antigens, CD
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CDH1 protein, human
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CTNNB1 protein, human
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Cadherins
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Snail Family Transcription Factors
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beta Catenin