Monoclonal antibodies against interleukin 13 and interleukin 31RA in development for atopic dermatitis

Abstract

The interleukin 13 (IL-13) and IL-31 cytokines and inflammatory pathways have been identified as important for the pathophysiology of atopic dermatitis (AD). Monoclonal antibodies against IL-13 have been studied for the treatment of asthma since 2011. More recently, 2 phase 2 trials have been completed with these antibodies in AD treatment. In both trials, significant reductions of Eczema Area and Severity Index scores were seen. IL-31 is thought to play a role transmitting itch sensation to the central nervous system, and blocking IL-31 activity reduces itch in patients with AD. One phase 2 trial has been completed for a humanized antibody against IL-31 receptor alpha, which is 1 subunit of the IL-31 receptor complex. This study showed significant dose-dependent reductions in pruritus, Eczema Area and Severity Index scores, and markers of sleep quality. Initial clinical trials for monoclonal antibodies against IL-13 and IL-31 receptor A all show promise, although long-term safety and efficacy data are lacking. Nevertheless, these medications will likely play a role in the treatment of moderate-to-severe AD.

Keywords: Eczema Area and Severity Index; IL-31RA; Investigator's Global Assessment; Janus kinase; STAT signal transducer and activator of transcription; T helper; Visual Analogue Scale; atopic dermatitis; c-Jun N-terminal kinase; dipeptidyl peptidase-4; interleukin; mitogen-activated protein kinase; oncostatin M receptor β; topical corticosteroids.