A Peek into Parkinson's Disease Progression through Human Dopamine Neurons in a Dish

Nan Yang; Zhenyu Yue

doi:10.1016/j.tins.2017.12.001

A Peek into Parkinson's Disease Progression through Human Dopamine Neurons in a Dish

Trends Neurosci. 2018 Feb;41(2):74-76. doi: 10.1016/j.tins.2017.12.001. Epub 2017 Dec 14.

Authors

Nan Yang¹, Zhenyu Yue²

Affiliations

¹ Department of Neuroscience, Friedman Brian Institute, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: nan.yang1@mssm.edu.
² Department of Neurology, Friedman Brian Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: zhenyu.yue@mssm.edu.

PMID: 29248177
DOI: 10.1016/j.tins.2017.12.001

Abstract

Using induced human dopamine (DA) neurons, a study by Burbulla and colleagues demonstrated a toxic cascade of cellular dysfunctions which may underlie Parkinson's disease (PD) progression. Their findings reveal what could be the causal relationship between multiple pathogenic pathways in human neurons obtained from idiopathic and familial cases, and suggest novel targets for therapeutic intervention.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Disease Progression
Dopamine
Dopaminergic Neurons*
Humans
Parkinson Disease*

Substances

Dopamine