Jagged1-induced Notch activation contributes to the acquisition of bortezomib resistance in myeloma cells

Blood Cancer J. 2017 Dec 15;7(12):650. doi: 10.1038/s41408-017-0001-3.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bortezomib / pharmacology*
  • Drug Resistance, Neoplasm / physiology*
  • Enzyme Activation / physiology
  • Humans
  • Jagged-1 Protein / metabolism*
  • Mice
  • Mice, Inbred NOD
  • Mice, SCID
  • Multiple Myeloma / metabolism
  • Multiple Myeloma / pathology*
  • Receptors, Notch / metabolism*
  • Signal Transduction / physiology
  • Xenograft Model Antitumor Assays

Substances

  • JAG1 protein, human
  • Jagged-1 Protein
  • Receptors, Notch
  • Bortezomib