Maternal liver transplant: Another cause of discordant fetal sex determination using cell-free DNA

Maria Neofytou; Nathalie Brison; Kris Van den Bogaert; Luc Dehaspe; Koen Devriendt; Anja Geerts; Joris R Vermeesch

doi:10.1002/pd.5194

Maternal liver transplant: Another cause of discordant fetal sex determination using cell-free DNA

Prenat Diagn. 2018 Jan;38(2):148-150. doi: 10.1002/pd.5194. Epub 2018 Jan 4.

Authors

Maria Neofytou¹, Nathalie Brison², Kris Van den Bogaert², Luc Dehaspe², Koen Devriendt², Anja Geerts³, Joris R Vermeesch^{1

2}

Affiliations

¹ Laboratory for Cytogenetics and Genome Research, KU Leuven, Leuven, Belgium.
² Centre for Human Genetics, KU Leuven, Leuven, Belgium.
³ Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium.

PMID: 29239474
DOI: 10.1002/pd.5194

Abstract

Noninvasive prenatal testing (NIPT) can very accurately determine fetal sex during pregnancy. We present an exceptional case where NIPT contradicts the ultrasound-based sex determination. The pregnant woman was recipient of a liver transplant from a male donor. Graft-derived cell-free DNA released into the maternal circulation clouded the NIPT-based sex determination. Hence, NIPT is not advisable when the pregnant mother underwent an organ transplant.

Publication types

Case Reports
Letter

MeSH terms

Cell-Free Nucleic Acids / blood*
Chromosomes, Human, Y / genetics*
Diagnostic Errors*
Female
Humans
Liver Transplantation*
Male
Pregnancy
Prenatal Diagnosis*
Sex Determination Analysis / methods*

Substances

Cell-Free Nucleic Acids