Rare side effect of adjuvant ipilimumab after surgical resection of melanoma: Guillain-Barré syndrome

BMJ Case Rep. 2017 Dec 13:2017:bcr2017221318. doi: 10.1136/bcr-2017-221318.

Abstract

Guillain-Barré syndrome is a life-threatening neurological disorder that presents with rapid ascending paralysis and areflexia. Guillain-Barré syndrome is traditionally associated with infections from a gastrointestinal or respiratory tract source. We report the case of a 71-year-old man with melanoma who was treated with ipilimumab as adjuvant immunotherapy and subsequently developed Guillain-Barré syndrome. The diagnosis was made clinically through physical exam findings. He was successfully treated with a combination of intravenous immunoglobulin therapy and corticosteroids.

Keywords: cancer intervention; chemotherapy; peripheral nerve disease; skin cancer; unwanted effects / adverse reactions.

Publication types

  • Case Reports

MeSH terms

  • Adjuvants, Immunologic / adverse effects
  • Adjuvants, Immunologic / therapeutic use*
  • Aged
  • Diagnosis, Differential
  • Guillain-Barre Syndrome / cerebrospinal fluid
  • Guillain-Barre Syndrome / chemically induced
  • Guillain-Barre Syndrome / diagnosis*
  • Humans
  • Immunoglobulins, Intravenous
  • Ipilimumab / adverse effects
  • Ipilimumab / therapeutic use*
  • Male
  • Melanoma / drug therapy*
  • Skin Neoplasms / drug therapy*

Substances

  • Adjuvants, Immunologic
  • Immunoglobulins, Intravenous
  • Ipilimumab