Pimentelamines A-C, Indole Alkaloids Isolated from the Leaves of the Australian Tree Flindersia pimenteliana

Luke P Robertson; Sandra Duffy; Yun Wang; Dongdong Wang; Vicky M Avery; Anthony R Carroll

doi:10.1021/acs.jnatprod.7b00587

Pimentelamines A-C, Indole Alkaloids Isolated from the Leaves of the Australian Tree Flindersia pimenteliana

J Nat Prod. 2017 Dec 22;80(12):3211-3217. doi: 10.1021/acs.jnatprod.7b00587. Epub 2017 Dec 13.

Authors

Luke P Robertson^{1

2}, Sandra Duffy², Yun Wang³, Dongdong Wang², Vicky M Avery², Anthony R Carroll^{1

2

3}

Affiliations

¹ Environmental Futures Research Institute, Griffith University , Southport 4222, Gold Coast, Australia.
² Griffith Institute for Drug Discovery, Griffith University , Nathan 4111, Brisbane, Australia.
³ Centre for Clean Environment and Energy, Griffith University , Southport 4222, Gold Coast, Australia.

PMID: 29236492
DOI: 10.1021/acs.jnatprod.7b00587

Abstract

Three members of a new class of ascorbic acid-adduct indole alkaloids (1-3), a new prenylated indole alkaloid (4), and five known compounds (5-9) were isolated from the leaves of Flindersia pimenteliana. The structures of 1-4 were elucidated on the basis of their (+)-HRESIMS and 2D NMR spectroscopic data. Antiplasmodial activity was also reported for the natural products against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum with IC₅₀ values ranging from 0.19 to 3.6 μM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antimalarials / chemistry
Antimalarials / pharmacology
Australia
Biological Products / chemistry
Biological Products / pharmacology
Indole Alkaloids / chemistry*
Indole Alkaloids / pharmacology
Magnetic Resonance Spectroscopy / methods
Plant Extracts / chemistry*
Plant Extracts / pharmacology
Plant Leaves / chemistry
Plasmodium falciparum / drug effects
Rutaceae / chemistry*
Trees / chemistry*

Substances

Antimalarials
Biological Products
Indole Alkaloids
Plant Extracts