Changing Epidemiology of Haemophilus influenzae in Children

Infect Dis Clin North Am. 2018 Mar;32(1):119-128. doi: 10.1016/j.idc.2017.10.005. Epub 2017 Dec 9.

Abstract

Haemophilus influenzae remains a common cause of illness in children throughout the world. Before the introduction of vaccination, H influenzae type b (Hib) disease was the leading cause of bacterial meningitis in young children and a frequent cause of pneumonia, epiglottitis, and septic arthritis. Clinicians should remain diligent in counseling parents on the dangers of Hib and provide vaccination starting at 2 months of age. The epidemiology of invasive H influenzae disease is shifting. It is imperative that clinicians recognize the changing epidemiology and antibiotic resistance patterns for H influenzae to optimize care in hospital and ambulatory settings.

Keywords: Children; H influenzae; Meningitis; Vaccination.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / therapeutic use
  • Bacteremia / epidemiology
  • Bacteremia / etiology
  • Bacteremia / microbiology
  • Cephalosporins / administration & dosage
  • Cephalosporins / therapeutic use
  • Child
  • Child, Preschool
  • Female
  • Haemophilus Infections / blood
  • Haemophilus Infections / complications
  • Haemophilus Infections / drug therapy
  • Haemophilus Infections / epidemiology*
  • Haemophilus influenzae type b / drug effects
  • Haemophilus influenzae type b / isolation & purification*
  • Humans
  • Incidence
  • Infant
  • Male
  • Meningitis, Bacterial / diagnosis
  • Meningitis, Bacterial / epidemiology
  • Meningitis, Bacterial / etiology
  • Meningitis, Bacterial / microbiology
  • Pneumonia / epidemiology
  • Pneumonia / etiology
  • Pneumonia / microbiology
  • Post-Exposure Prophylaxis
  • Rifampin / administration & dosage
  • Rifampin / therapeutic use
  • Vaccination

Substances

  • Anti-Bacterial Agents
  • Cephalosporins
  • Rifampin