[Overview of feelings and practices of gynecologists and obstetricians for the noninvasive prenatal testing in France]

Abstract

Objectives: To evaluate the feelings and practices of French obstetrician-gynecologists in prescribing the noninvasive prenatal testing (NIPT) before the release of the French High Authority of Health recommendations.

Methods: Descriptive, declarative and transversal study, analyzing the feelings and practices of obstetrician-gynecologists, members of the French College of Gynecologists and Obstetricians (CNGOF) between February and May 2017 using an online questionnaire. Practitioners' feedback was self-assessed for several clinical situations using a numerical scale ranging from 1 to 10. This experience was rated as "good" (grades 6 to 10) or "bad" (grades 1-5).

Results: Overall, 529 practitioners (29.2%) of 1812 CNGOF members, answered the online questionnaire. A "good" feeling was found for more than 65% of the practitioners audited. Feelings were significantly better for obstetricians, sonographers (P<0.05) and CPDPN members (P=0.003) compared to other practitioners. Situations where the DPNI was proposed "systematically" were risks greater than 1/250 (70.9%), between 1/250 and 1/500 (59.4%), greater than 1/250 associated with history of spontaneous miscarriages and/or fetal death in utero (66%), greater than 1/250 associated with pregnancy resulting from PMA (68.3%), history of fetal aneuploidy (54%) and a parent carrying a Robertsonian translocation (51.6%).

Conclusion: This study highlights a good overall feeling of the practitioners with the NIPT.

Keywords: Aneuploidy; Aneuploïdies; Collège national des gynécologues obstétriciens français; Down syndrome; Dépistage combiné du premier trimestre; Dépistage prénatal non invasif; French National College of Gynaecologists and Obstetricians; Non invasive prenatal testing; Prenatal screening; Trisomie 21.